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Significats de genome instability en anglès
espanyol
inestabilidad genómica Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.
Sinònims
Examples for "genetic instability"
Examples for "genetic instability"
1
However, our data impressively demonstrate the genetic instability in this chromosomal region.
2
Oxidative DNA damage seems to contribute to genetic instability observed in cancer.
3
Background: Latent genetic instability has been associated with an increased risk for several cancers.
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However, their inherent genetic instability hinders application for prophylactic purposes.
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Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma.
1
Cells from patients with genomic instability syndromes have high predisposition to cancer.
2
Deregulated activation of β-catenin in cancer has been correlated with genomic instability.
3
Moreover, the different patterns of alteration imply distinct underlying mechanisms of genomic instability.
4
NOS-induced ROS release leads to DNA damage and genomic instability in DMD hPSC.
5
Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability.
Ús de genome instability en anglès
1
Our present knowledge of the molecular basis underlying genome instability is extremely limited.
2
Here, we present evidence that MLL2 mutation results in genome instability.
3
Cells with a faulty protective mechanism undergo defective mitosis, leading to genome instability.
4
Human MLL2 knockout cells are characterized by genome instability as well.
5
Defects in the genes encoding the Paf1 complex can cause increased genome instability.
6
Mutations in proteins that constitute these repair pathways are characterised by radiosensitivity and genome instability.
7
Our data showed that additional transcription unit insertion could confer genome instability and attenuation of HP-PRRSV.
8
We therefore propose that sequential degradation ensures orderly S-phase progression to avoid replication stress and genome instability.
9
Thus, neither genome instability nor lack of immunosurveillance conferred by scid contributes to intestinal polyps in this model.
10
The de novo assembly resulted in unmasking hidden genome instability that was missed by standard re-alignment based algorithms.
11
The pre-BCR also promotes cell cycle entry, which could cause aberrant DSB repair and genome instability in pre-B cells.
12
Retrotransposons are populated in vertebrate genomes , and when active, are thought to cause genome instability with potential benefit to genome evolution.
13
Our studies provide new insights into understanding the genomic landscape, genome instability, and mutation profile underlying gastric cancer and ESCC development.
14
Epigenetic perturbations are increasingly described in cancer cells where they are thought to contribute to deregulated gene expression and genome instability.
15
From E. coli to yeast to human cells, subtle alterations in expression of BER proteins lead to mutagenic or genome instability phenotypes.
16
We propose that loss of HR control after deregulation of RTEL1 may be a critical event that drives genome instability and cancer.
Translations for genome instability